Glycosaminoglycans modulate RANKL-induced osteoclastogenesis
نویسندگان
چکیده
منابع مشابه
TRPM7 Is Essential for RANKL-Induced Osteoclastogenesis
The transient receptor potential melastatin type 7 (TRPM7) channel is a widely expressed non-selective cation channel with fusion to the C-terminal alpha kinase domain and regarded as a key regulator of whole body Mg(2+) homeostasis in mammals. However, the roles of TRPM7 during osteoclastogenesis in RAW264.7 cells and bone marrow-derived monocyte/macrophage precursor cells (BMMs) are not clear...
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The bone-resorbing osteoclast (OC) is essential for bone homeostasis, yet deregulation of OCs contributes to diseases such as osteoporosis, osteopetrosis, and rheumatoid arthritis. Here we show that histone deacetylase 2 (HDAC2) is a key positive regulator during receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclastogenesis and bone resorption. Bone marrow macrophages (BMMs)...
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ژورنال
عنوان ژورنال: Journal of Cellular Biochemistry
سال: 2010
ISSN: 0730-2312,1097-4644
DOI: 10.1002/jcb.22506